本文对肺心病54例和对照组23例的动脉血气、红细胞内pH(pHi)、2,3-二磷酸甘油酸(2,3-DPG)、标准P_(50)(P_(50(std)))和体内P_(50)(P_(50(iv)))进行了研究。结果表明,肺心病人pHi无明显变化,但红细胞内外pH差降低;肺心病Ⅱ型呼吸衰竭人P_(50(std))降低(P<0.05),而P_(50(iv))无明显变化。提示:肺心病人P_(50(std))不能准确反映P_(50(iv))变化;P_(50(iv))相对稳定、与“最佳P_(50)”相吻合,是机体对慢性缺氧的一种适应;红细胞内相对偏碱对缓解高碳酸血症引起的氧离曲线过度右移起重要作用 In this paper, 54 cases of pulmonary heart disease and 23 cases of control group arterial blood gas, intracellular pH (pHi), 2,3-diphosphoglycerate (2,3-DPG), standard P_ (50) ) And P_ (50) (P_ (50 (iv)) in vivo). The results showed that there was no significant change of pHi in pulmonary heart disease patients, but the pH difference between the inside and outside of erythrocytes was decreased. The P_ (50 (std)) of pulmonary heart disease patients with type Ⅱ respiratory failure were decreased (P <0.05) . (50 (iv)) is relatively stable, and consistent with the “best P 50”, is the body of the chronic Hypoxic adaptation; red blood cell is relatively alkaline to relieve hypercapnia caused by the excessive shift of the oxygen ion curve plays an important role