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胆道系统肿瘤是一类具有遗传多样性的恶性肿瘤,主要包括肝内胆管癌、肝外胆管癌和胆囊癌。多数患者确诊时多无法手术切除或发生转移,预后较差。手术和放疗在晚期胆系恶性肿瘤中的作用有限。化疗作为主要的治疗选择,研究显示传统化疗的有效率可达10%～40%。吉西他滨联合顺铂的化疗方案可显著延长患者的生存期,被认为是标准的治疗方案。分子靶向治疗在晚期胆系肿瘤中效果令人欣悦,但仍需进一步深入研究。
Biliary system tumors are a group of malignant tumors of genetic diversity, including intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma and gallbladder cancer. Most patients diagnosed when more than surgery or metastasis, the prognosis is poor. The role of surgery and radiotherapy in advanced gallbladder malignancies is limited. Chemotherapy as the main treatment option, studies have shown that the efficiency of traditional chemotherapy up to 10% to 40%. Chemotherapy with gemcitabine plus cisplatin has been shown to significantly improve patient survival and is considered the standard treatment. Molecular targeted therapy is pleasing in advanced cholangiocarcinoma, but further research is still needed.