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目的:探讨血清促甲状腺素(TSH)水平对高尿酸血症患病率的影响。方法:回顾性分析20岁以上健康体检者2252例的临床资料。结果:(1)高尿酸血症的患病率为14.2%,其中男性19.3%,女性9.6%。(2)甲状腺功能异常患病率为9.0%,男性3.1%,其中TSH降低者0.7%,TSH升高者2.5%;女性14.2%,其中TSH降低者4.2%,TSH升高者10.0%。(3)与TSH正常组相比,不论性别,TSH升高组的血尿酸水平均显著升高(P<0.05),TSH降低组的血尿酸水平无显著变化。(4)TSH升高是高尿酸血症的独立影响因素(OR值男性为1.75,女性为1.83,P均<0.01)。结论:高尿酸血症患病率与血清TSH升高显著相关,临床或亚临床甲状腺功能减退症可能是高尿酸血症的危险因素。
Objective: To investigate the effect of serum thyrotropin (TSH) on the prevalence of hyperuricemia. Methods: The clinical data of 2252 healthy people over the age of 20 were retrospectively analyzed. Results: (1) The prevalence of hyperuricemia was 14.2%, of which 19.3% were male and 9.6% were female. (2) The prevalence of abnormal thyroid function was 9.0% in men and 3.1% in males. Among them, TSH was decreased by 0.7%, TSH was increased by 2.5%, females was 14.2%, TSH was decreased by 4.2% and TSH was increased by 10.0%. (3) Compared with the normal TSH group, regardless of sex, serum uric acid levels were significantly increased in the TSH-elevated group (P <0.05), while there was no significant change in the TSH-reduced group. (4) Elevated TSH is an independent factor of hyperuricemia (OR = 1.75 for males and 1.83 for females, P <0.01 for all). CONCLUSIONS: The prevalence of hyperuricemia is significantly associated with elevated serum TSH. Clinical or subclinical hypothyroidism may be a risk factor for hyperuricemia.