早老症于1886年由Hutchinson首次报告,后经Gilford进一步描述,故此病又称Hutchinson-Gilford综合征。此病为一种较罕见的常染色体隐性遗传性疾病,表现全身复合性缺陷并侵犯心血管系统,以发育缓慢、侏儒、消瘦、过早脱发、衰老、血压升高及动脉硬化为主要表现。患儿似老人容貌,故而又称早老症。我院自1979～1998年共收治7例,现综合临床、实验室检查及X线表现做如下分析。 1 临床资料 1.1 一般资料 本组7例,男3例,女4例。最小2岁2个月,最大9岁。5例在2岁以后发病。3例系第一胎足月顺产,生后正常,4例第2胎第2产,早产。7例家族中无类似病人。其中1例的父母为近亲结婚(姑舅亲)。 1.2 临床特征 7例患儿身高、体重、头围、胸围均低于同 Alzheimer’s first reported by Hutchinson in 1886, further described by Gilford, so the disease is also known as Hutchinson-Gilford syndrome. The disease is a rare autosomal recessive inherited disease that manifests systemic complex defects and invades the cardiovascular system, with slow development, dwarfism, weight loss, premature hair loss, aging, elevated blood pressure and atherosclerosis . Children like elderly appearance, it is also known as premature. Our hospital since 1979 ~ 1998 were treated in 7 cases, is now integrated clinical, laboratory tests and X-ray findings do the following analysis. 1 Clinical data 1.1 General Information The group of 7 patients, 3 males and 4 females. Minimum 2 years old 2 months, maximum 9 years old. Five cases of disease after 2 years of age. Three cases of full-term first-term birth of the fetus, normal after birth, 4 cases of second-born 2, premature delivery. None of the seven families had a similar patient. One of the parents was married (relatives). 1.2 Clinical Features 7 cases of children with height, weight, head circumference, chest circumference were lower than the same