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脑膜瘤是颅内常见肿瘤,其发病率仪次于胶质瘤,约占脑肿瘤总数的20%。外科于术治疗效果较好,但脑膜瘤全切术后仍有一定的复发倾向。Rene等报告,145例脑膜瘤行全切除术后5年、10年和15年的复发率分别为7%、20%和32%。长期以来,肿瘤的切除程度和肿瘤的病理类型一直被认为是影响脑膜瘤术后复发的主要因素,随着研究的不断深入,特别是通过分子生物学的研究,还发现多种因素如肿瘤细胞增殖指数、抑癌基因、端粒酶活性、基质金属蛋白酶、激素受体及生长因子等均与脑膜瘤的复发关系密切;此外,影像学特征也是相关因素之一。本文对近年来相关报道综述如下。
Meningioma is a common intracranial tumor, the incidence rate of glioma, accounting for about 20% of the total number of brain tumors. Surgery in the surgical treatment is better, but there is still a certain tendency of recurrence after meningioma resection. Rene et al. Reported that the recurrence rates at 5, 10 and 15 years after total resection in 145 cases of meningiomas were 7%, 20% and 32%, respectively. For a long time, tumor resection degree and tumor pathological type have been considered as the main factors affecting the recurrence of meningioma. With the deepening of the research, especially through the research of molecular biology, it is also found that a variety of factors such as tumor cells Proliferation index, tumor suppressor gene, telomerase activity, matrix metalloproteinases, hormone receptors and growth factors are closely related with the recurrence of meningiomas; In addition, the imaging features are also related factors. This article summarizes the related reports in recent years as follows.