细菌触发型靶向释药系统是依据人体结肠独特的菌群分布 ,利用细菌具有的偶氮还原酶、糖苷酶及糖苷酸酶等多种酶 ,能生物降解药物载体 ,使药物在结肠定位释放。按释药机制和给药方式 ,细菌触发型结肠释药系统可分为 4类 :前体药物释药系统、多糖载体释药系统、联合pH依赖型或时滞型的复合释药系统、偶氮芳香族水性凝胶释药系统。它们需采用独特的溶出性试验评价药物的体外释放和γ 闪烁照相法观察药物的体内行为 ,本文对该领域的研究进展作一综述 Bacterial-triggered targeted release system is based on the distribution of the unique colony of the human colon, the use of bacteria with azo reductase, glycosidase and glycosidase and other enzymes, biodegradable drug carrier, the drug released in the colon positioning . According to drug release mechanism and mode of administration, the bacterial triggered colon delivery system can be divided into four categories: prodrug release system, polysaccharide carrier release system, combined pH-dependent or time-lag compound release system, even Nitrogen Aromatic Aqueous Gel Release System. They require a unique dissolution test to evaluate in vitro drug release and gamma scintigraphy to observe the in vivo behavior of the drug. This review summarizes the advances in this field