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目的:通过对比Wnt5A在伴或不伴鼻息肉的慢性鼻鼻窦炎(CRSwNP或CRSsNP)及正常鼻黏膜组织中的表达差异,探讨Wnt5A与CRS发病之间的联系。方法:应用免疫组织化学染色检测Wnt5A及pLRP6在CRSwNP和(或)CRSsNP组织中的表达状态,比较其间的差异。结果:Wnt5A在CRSwNP组中的表达明显较对照组及CRSsNP组增强(P<0.01),阳性染色主要见于炎性细胞及上皮细胞;而CRSwNP组中pLRP6表达则低于对照组(P<0.01)。结论:Wnt5A在CRSwNP组织中的表达上调提示Wnt5A可能参与CRSwNP的发病。
OBJECTIVE: To investigate the relationship between Wnt5A and the pathogenesis of CRS by comparing the expression of Wnt5A in chronic rhinosinusitis (CRSwNP or CRSsNP) and normal nasal mucosa with or without nasal polyps. Methods: The expression of Wnt5A and pLRP6 in CRSwNP and / or CRSsNP tissues was detected by immunohistochemical staining, and the differences were compared. Results: The expression of Wnt5A in CRSwNP group was significantly higher than that in control group and CRSsNP group (P <0.01). The positive staining was mainly found in inflammatory cells and epithelial cells. The expression of pLRP6 in CRSwNP group was lower than that in control group (P <0.01) . Conclusion: Upregulation of Wnt5A in CRSwNP tissues suggests that Wnt5A may be involved in the pathogenesis of CRSwNP.