基因印迹是不遵循孟德尔遗传规律的一种依靠单亲传递某些遗传学性状的现象,即某些基因呈亲源依赖性的单等位基因表达,另一等位基因不表达或表达极弱。配子和早期胚胎形成期是甲基化印迹擦除、建立和维持的关键窗口期,而此期恰为辅助生殖技术体外干预阶段,可能干扰基因组印迹的建立和维持,导致遗传性印迹病的产生。 Gene blotting is a phenomenon that does not follow the Mendelian law of inheritance and relies on the single parental transmission of certain genetic traits, that is, some genes are genetically dependent single alleles and the other allele is not expressed or expressed very weakly . Gamete and early embryogenesis is a critical window for erased, established and maintained methylated imprinting, which is just the stage of in vitro intervention by assisted reproductive technology and may interfere with the establishment and maintenance of genomic imprinting, leading to the development of hereditary imprinting disease .