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目的 :探讨脉络宁对重型肝炎患者血小板活性的影响。方法 :采用ELISA法和单克隆酶联免疫吸附法 ,检测了 51例慢性重型肝炎患者和 4 4例健康体检者的血浆内血小板α颗粒膜蛋白 (GMP 1 4 0 )和血管性假血友病因子相关抗原 (vWF∶Ag)含量。 51例慢性重型肝炎患者 ,随机分为两组 :一般治疗组和脉络宁治疗组 (在一般治疗基础上加用脉络宁 ) ,疗程两周。结果 :慢性重型肝炎患者血浆GMP 1 4 0、vWF∶Ag含量均明显高于正常对照组 (P <0 .0 1 )。脉络宁治疗组用药两周后 ,血浆GMP 1 4 0、vWF∶Ag水平均明显下降 (P <0 .0 1 )。结论 :慢性重型肝炎患者血小板处于明显活化状态 ,脉络宁对该病患者的血小板活性具有明显抑制作用。
Objective: To investigate the effect of Mailuoning on platelet activity in patients with severe hepatitis. Methods: The plasma level of platelet α-granule membrane protein (GMP-140) and von Willebrand’s disease in 51 patients with chronic severe hepatitis and 44 healthy individuals were detected by ELISA and monoclonal antibody-linked immunosorbent assay Factor related antigen (vWF: Ag) content. 51 patients with chronic severe hepatitis were randomly divided into two groups: general treatment group and Mailuoning treatment group (based on the general treatment with Mailuoning) for two weeks. Results: The levels of plasma GMP 1 40 and vWF: Ag in patients with chronic severe hepatitis were significantly higher than those in the normal control group (P <0.01). Mailuoning treatment group after two weeks of medication, plasma GMP 1 40, vWF: Ag levels were significantly decreased (P <0.01). Conclusion: The platelet of patients with chronic severe hepatitis is obviously activated, and Mailuoning can obviously inhibit the platelet activity of the patients.