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目的 :动态比较一氧化氮 (NO)供体硝酸甘油与硫酸镁治疗中重度妊高征 (PIHS)的作用。方法 :通过监测两组患者用药前后平均动脉压 (MAP)、疗程及母儿结局等指标来评价二者的治疗效果。结果 :硝酸甘油治疗组降低的患者MAP及缓解头痛症状较硫酸镁治疗组迅速 (P <0 0 5 ) ;硫酸镁组疗程较硝酸甘油组长(P <0 0 5 ) ;硫酸镁治疗组临床诊断胎儿宫内窘迫发生率较硝酸甘油治疗组高 (P <0 0 5 ) ;但新生儿窒息、产后失血两组差异无显著性 (P >0 0 5 )。结论 :硝酸甘油治疗中重度妊高征与硫酸镁治疗效果相比 ,在降低MAP及稳定MAP方面优于硫酸镁 ,且有不干扰胎儿宫内窘迫临床诊断等优点。
Objective: To dynamically compare the effects of nitric oxide (NO) donor nitroglycerin and magnesium sulfate in the treatment of moderate and severe pregnancy-induced hypertension (PIHS). Methods: The therapeutic effects of the two groups were evaluated by monitoring the mean arterial pressure (MAP), duration of treatment and maternal and child outcomes before and after treatment. Results: Compared with the group treated with magnesium sulfate, the symptoms of MAP and headache relieved in the patients treated with nitroglycerin were quicker than those treated with magnesium sulfate (P <0.05); those treated with magnesium sulfate were longer than those treated with nitroglycerin (P <0.05) The incidence of fetal distress was higher in patients diagnosed with nitroglycerin than in those treated with nitroglycerin (P <0.05). However, there was no significant difference in neonatal asphyxia and postpartum blood loss between the two groups (P> 0.05). CONCLUSION: Nitroglycerin is superior to magnesium sulfate in reducing MAP and stable MAP when compared with magnesium sulfate in the treatment of moderate-severe pregnancy-induced hypertension and has the advantage of not interfering with the clinical diagnosis of fetal distress.