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Castleman病又称巨大淋巴结增生症,是一个较为少见的良性淋巴组织增生性疾病,病因不清。其临床上分为单中心型和多中心型,组织病理学上分为透明血管型、浆细胞型和混合型。在临床过程中,不同的分型有着不完全一致的治疗和预后。作者主要从Castleman病发病机制、治疗和预后等方面进行综述,并着重强调透明血管型Castleman病中的一个特殊亚型—间质增生型。
Castleman disease, also known as giant lymph node hyperplasia, is a relatively rare benign lymphoproliferative disease, the etiology is unclear. Clinically, it is divided into single-center and multi-center type, histopathologically divided into transparent vascular type, plasma cell type and mixed type. In the clinical course, different types have incomplete and consistent treatment and prognosis. The author mainly reviews the pathogenesis, treatment and prognosis of Castleman’s disease, and highlights a special subtype of interstitial hyperplasia of Castleman’s disease.