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自1966年Clark关于把小鼠浸入Fx-80几小时,回到大气后仍能活存的报导发表后,引起人们对氟碳人工血液研究的兴趣。此后,Sloviter,用Fx-80灌注大鼠离体脑,Geyer用Fc-43/F-68为大鼠换血均获得成功。1969年,在莫斯科国际输血学会第十二次会议上,对氟碳人工血液问题进行了第一次讨论。1970年开始,日本以光野、大柳为主,与绿十字中央研究所,田道制药综合研究所共同对全氟荼烷(FDC)进行了较深入的研究。1974年4月,在美国国立卫生研究院心肺研究所血液病和血液资源部第二次人工血液讨论会上,进一步解决了对氟碳化合物用作人工血液所存在的某些问题。这几年,已在猴子身上进行了动物试验。
Since the publication of Clark’s report of 1966, when mice were immersed in Fx-80 for several hours and were still alive after returning to the atmosphere, the interest in fluorocarbon artificial blood research has been raised. Since then, Sloviter, Fx-80 perfusion rat isolated brain, Geyer Fc-43 / F-68 rat blood exchange were successful. In 1969, at the twelfth meeting of the International Society of Transfusion Medicine in Moscow, the first discussion on artificial blood of fluorocarbons was held. Beginning in 1970, Japan mainly focused on the fields of light and Dali, and conducted a thorough study on the tetrachlorodifarn (FDC) with the Green Cross Central Research Institute and the Tian Road Institute of Pharmaceutical Research. In April 1974, some problems with the use of fluorocarbons as artificial blood were further addressed at the Second Artificial Blood Symposium of the Department of Hematology and Blood Resources of the Cardiovascular Research Institute of the National Institutes of Health. In recent years, animals have been tested on monkeys.