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目的:探讨妊娠糖尿病前期早期干预及胎儿健康状况的效果评价。方法:筛查的2 379例孕妇中,空腹血糖受损88例,糖耐量受损364例,知情同意后共400例参与项目研究,并随机分为干预组及对照组各200例。对干预组实施早期干预模式,比较两组的糖耐量受损、相关生化指标及妊娠高危及并发症情况。结果:干预组干预后GDM、GIGT持续、持续空腹血糖受损、产后OGTT的发生率均低于对照组,非炎症反应(C反应蛋白)的发生率高于对照组,羊水过多、巨大儿的发生率低于对照组,胎儿生长发育指数干预组良好率高于对照组,以上差异均具有统计学意义(P<0.05)。结论:实施妊娠期糖尿病前期早期干预有利于降低GDM发病率,减少并发症,促进母婴安康。
Objective: To evaluate the effect of early intervention in gestational diabetes mellitus and fetal health status. Methods: Among 2 379 pregnant women who were screened, there were 88 cases of impaired fasting glucose and 364 cases of impaired glucose tolerance. A total of 400 cases were involved in the study after informed consent and were randomly divided into intervention group and control group with 200 cases each. Intervention group, the implementation of early intervention mode, compared impaired glucose tolerance, biochemical indicators and high risk of pregnancy and complications. Results: After intervention, GDM and GIGT persisted, sustained impaired fasting glucose and the incidence of postpartum OGTT were lower than those of the control group. The incidence of non-inflammatory reaction (C-reactive protein) was higher in the intervention group than in the control group (P <0.05). The good rate of fetal growth index was higher in the intervention group than in the control group. The above differences were statistically significant (P <0.05). Conclusion: The implementation of early intervention in gestational diabetes mellitus is conducive to reduce the incidence of GDM, reduce complications and promote the well-being of mothers and children.