论文部分内容阅读
目的探讨诱导化疗联合同期放化疗治疗局部晚期鼻咽癌的安全性有效性。方法收集2003年10月～2007年8月56例局部晚期鼻咽癌患者(Ⅲ,Ⅳa,92分期),于同期放化疗前接受2～3个疗程的诱导化疗,观察治疗效果。结果56例患者所有的患者完成了计划剂量的治疗。诱导化疗结束后,鼻咽完全缓解率为19.6%,颈部淋巴结完全缓解率为31.6%。放疗结束3个月后,鼻咽完全缓解率为98.2%,颈部淋巴结完全缓解率为94.7%。以PF方案行诱导化疗患者耐受性好,同期放化疗期间,37.5%患者发生了3度粘膜炎,18%患者发生了3度呕吐反应。中位随访30个月后,2年总的生存率(OS)为92.8%。结论以诱导化疗联合同期放化疗的方式治疗局部晚期鼻咽癌方式,患者耐受性好,且能获得较好的治疗效果。
Objective To investigate the safety and efficacy of induction chemotherapy combined with concurrent chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma. Methods 56 patients with locally advanced nasopharyngeal carcinoma (Ⅲ, Ⅳa, 92 stage) from October 2003 to August 2007 were enrolled. Two to three courses of induction chemotherapy were given before radiotherapy and chemotherapy in the same period. The therapeutic effect was observed. Results All patients in 56 patients completed the planned dose of treatment. After induction of chemotherapy, the complete remission rate of nasopharyngeal was 19.6%, cervical lymph node complete remission rate was 31.6%. Three months after the end of radiotherapy, the complete remission rate of nasopharynx was 98.2% and the complete remission rate of cervical lymph node was 94.7%. In the PF regimen, chemotherapy-induced patients were well tolerated. During the same period of chemoradiotherapy, 37.5% had 3-degree mucositis and 18% had 3-degree vomiting. After a median follow-up of 30 months, the 2-year overall survival (OS) was 92.8%. Conclusion Induction chemotherapy combined with concurrent radiotherapy and chemotherapy approach to the treatment of locally advanced nasopharyngeal carcinoma, patients with good tolerance, and can get better therapeutic effect.