目的　探讨基质金属蛋白酶 9(MMP 9)水平在胎膜早破孕妇血浆和羊水中的变化及与胎膜早破的关系。方法　 2 0 0 1年 2～ 12月采用酶联免疫吸附法对 2 6例胎膜早破孕妇和 2 0例正常妊娠孕妇血浆、羊水中MMP 9水平进行检测。结果　胎膜早破孕妇血浆与羊水中MMP 9水平分别为 4 2 2 2 7ng/L、187 2ng/L ,均明显高于对照组 ,差异有显著性意义 (P <0 0 1)。结论　MMP 9与胎膜早破有关 ,当MMP 9高于 35 0 0ng/L时 ,易发生胎膜早破 ,需及时采取预防措施。 Objective To investigate the changes of matrix metalloproteinase 9 (MMP 9) levels in plasma and amniotic fluid of pregnant women with premature rupture of membranes and their relationship with premature rupture of membranes. Methods From February to December 2001, MMP-9 levels in 26 cases of premature rupture of membranes and 20 cases of normal pregnant women were detected by enzyme-linked immunosorbent assay. Results The levels of MMP-9 in plasma and amniotic fluid of pregnant women with premature rupture of membranes were 42227ng / L and 187 2ng / L, respectively, which were significantly higher than those in the control group (P <0.01). Conclusion MMP 9 is associated with premature rupture of membranes. When MMP 9 is higher than 35 0 0 ng / L, premature rupture of membrane premature rupture is required. Preventive measures should be taken in time.