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Metergoline 是一种抗5羟色胺活性的降低血泌乳素(PRL)水平药物,能使正常受试者和高泌乳素血症病人的血 PRL 分泌下降,并使后者症状消失,生育力恢复。本文评价了 metergoline 在处理特发性正常泌乳素血症继发闭经病人中的作用。对108例具有正常血清 PRL 水平,确诊为特发性闭经持续6月以上(平均23.4±0.38月)的患者进行了试验。开始时住院检查,询问病史,物理、妇科及实验室(血尿常规、肝肾功能、大便潜血、血 FSH、LH、PRL孕酮、T_3、T_4,尿17KS、17OHCS)检查,其余实验内容每2周一次在门诊随查。住院期间10
Metergoline, an anti-serotonin-lowering, prolactin (PRL) -like drug, reduces blood PRL secretion in normal subjects and hyperprolactinemia patients and renders the latter symptom-free and fertility restored. This article assesses the role of metergoline in treating patients with amenorrhea secondary to idiopathic normal prolactinemia. A trial of 108 patients with normal serum PRL levels who were diagnosed with idiopathic amenorrhea for more than 6 months (mean, 23.4 ± 0.38 months) was performed. At the beginning of hospitalization, medical records, physical examination, gynecology and laboratory tests (hematuria, liver and kidney function, fecal occult blood, blood FSH, LH, PRL progesterone, T_3, T_4, urine 17KS, 17OHCS) Once in the clinic with the investigation. During hospitalization 10