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由微生物产生的次级代谢产物肽,无论在化学结构或生物活性上都具有多样性.这类代谢产物包括着抗生素、酶抑制剂、植物或动物毒素和免疫抑制剂等,在医学、农学和生物学研究上都有重要的意义.早己鉴定过两种氨基酸拼入活性多肽的机理.譬如,多环抗生素是由基因编码的肽前体核糖体合成的,而这些肽前体经复合的翻译后加工(Post-translational processing)被广泛加以修饰.另一些肽则是以一种非核糖体的机理,在蛋白质的模板上合成的.这种合成提供了结构多种多样的肽次级代谢产物,它们可由线状的、环状的或分支的肽链组成;可含有D型-、羟基-或N甲基-氨基酸,这些氨基酸又可做酰基化或糖基化等修饰.
Secondary metabolite peptides produced by microorganisms, regardless of their chemical structure or biological activity, include antibiotics, enzyme inhibitors, plant or animal toxins and immunosuppressants, and are widely used in medicine, agronomy and Biological research have important significance.However, two kinds of amino acids have been identified into the active polypeptide mechanism.For example, polycyclic antibiotics are encoded by the gene precursor peptide ribosome synthesis, and the precursor of these peptides by complex Post-translational processing has been extensively modified, while others have been synthesized on protein templates in a non-ribosomal machinery that provides a diverse array of peptide secondary metabolites Products, which may consist of linear, cyclic or branched peptide chains; may contain D-type, hydroxy- or N-methyl-amino acids, which in turn may be acylated or glycosylated and the like.