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日人井上哲男所著《医药品添加物》(1972)第109～115页载有一些防腐剂的主要性状、半数致死量、使用浓度等资料,颇有参考价值,特摘要作一介绍,供有关方面参阅。说明:原文是表格,为节约篇幅,改用文字分条叙述。(1)——指其水溶液酸碱性;(2)——指在水中的溶解度(g/100ml);(3)——指在乙醇中的溶解度(g/100 ml);(4)——指 LD_(50)(mg/kg);(5)——指有效浓度(%);“内”代表内用液剂,“眼”代表眼科用液剂,“注”代表注射剂,“软”代表软膏剂。对羟苯甲酸甲酯:(1)微酸性至中性;(2)0.1;(3)37;(4)狗,经口,3000;(5)内0.05,眼0.05,注0.05～0.18,软0.1～0.2。
Japanese Inoue Tetsuo, “Medicine Additives” (1972), pages 109 ~ 115 contains some of the main characters of preservatives, the median lethal dose, the use of concentration and other information, quite a reference value, special abstracts to make an introduction for See the relevant parties. Description: The original is the form, in order to save space, use the text slides narrative. (2) - refers to the solubility in water (g / 100ml); (3) - refers to the solubility in ethanol (g / 100ml); (4) - - refers to the LD_ (50) (mg / kg); (5) - refers to the effective concentration (%); “inside” represents the internal liquid agent, “eye” represents ophthalmic liquid agent, “On behalf of the injection, ” soft "represents the ointment. Methyl paraben: (1) slightly acidic to neutral; (2) 0.1; (3) 37; (4) dog, oral, 3000; Soft 0.1 ~ 0.2.