棉酚是一种作用干睾丸的抗精子发生药物、损伤变态过程的精子细胞和中晚期精母细胞,近期亦有人报道棉酚能进一步损伤精原细胞与间质细胞,但棉酚对人垂体性腺轴系激素的影响报道不多。本文通过测定服用棉酚1～79个月的男子血中睾丸酮,LH和FSH含量的变化,探讨棉酚对人垂体性腺轴系的影响、观察棉酚对睾丸间质细胞及生精上皮的损伤作用。 Gossypol is an anti-spermatogenic drug that acts on dry testicles, damaging the metamorphosis process of spermatids and late-stage spermatocytes. It has also been recently reported that gossypol can further damage spermatogonia and interstitial cells, but gossypol can inhibit human pituitary Gonadal axis hormone effects reported little. In this paper, menstrual blood testosterone, LH and FSH content in gypenosorbate in males aged from 1 to 79 months were measured to explore the effect of gossypol on the gonadal axis of human pituitary gland and to observe the damage of gossypol to testicular interstitial cells and seminiferous epithelium effect.