最近有人指出血浆游离脂肪酸 (FFA)水平升高是联系肥胖、胰岛素抵抗 (IR)和 2型糖尿病的一个重要因素。现就FFA致IR和 2型糖尿病的机制作一综述。1　FFA与肥胖、IR和 2型糖尿病最近有人指出 2型糖尿病的发生与脂代谢异常的关系比与糖代谢异常的关系更为密切 ,其依据是[1] :在美 Recently, it has been pointed out that elevated plasma levels of free fatty acids (FFA) are an important factor in obesity, insulin resistance (IR) and type 2 diabetes. The mechanisms of FFA-induced IR and type 2 diabetes are reviewed. 1 FFA and obesity, IR and type 2 diabetes Recently, it was pointed out that the incidence of type 2 diabetes and lipid metabolism than the abnormal relationship with glucose metabolism more closely linked to its basis is [1]: in the United States