【摘 要】
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Investigation of pain requires measurements of nociceptive sensitivity and other pain-related behaviors.Recent studies have indicated the superiority of gait analysis over traditional evaluations (e.g.,skin sensitivity and sciatic function index [SFI]) in
【机 构】
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Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Ke
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Investigation of pain requires measurements of nociceptive sensitivity and other pain-related behaviors.Recent studies have indicated the superiority of gait analysis over traditional evaluations (e.g.,skin sensitivity and sciatic function index [SFI]) in detecting subtle improvements and deteriorations in animal models.Here,pain-related gait parameters,whose criteria include (1) alteration in pain models,(2) correlation with nociceptive threshold,and (3) normalization by analgesics,were identified in representative models of neuropathic pain (spared nerve injury:coordination data) and inflammatory pain (intraplantar complete Freund\'s adjuvant:both coordination and intensity data) in the DigiGaitTM and CatWalkTM systems.DigiGaitTM had advantages in fixed speed (controlled by treadmill) and dynamic SFI,while CatWalkTM excelled in intrinsic velocity,intensity data,and high-quality 3D images.Insights into the applicability of each system may provide guidance for selecting the appropriate gait imaging system for different animal models and optimization for future pain research.
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