【目的】探讨解痉灵复合丙泊酚用于无痛胃肠镜麻醉的临床效果和安全性，并统计患者的舒适度和满意度。【方法】对接受胃肠镜检查的400名检查者进行分组：A组常规胃肠镜检查静脉注射解痉灵复合丙泊酚、B组常规胃肠镜检查静脉注射解痉灵、C组常规胃肠镜检查静脉注射丙泊酚、D组行常规胃肠镜检查；每组100例。记录各组用药前、术中、苏醒时平均动脉压（MAP）、心率（HR）、脉搏血氧饱和度（SpO2）；术中记录患者的不良反应；术后调查患者的舒适度和满意度来并记录手术时间。【结果】相比B、C、D组，A组患者手术过程中出现的不良反应较少，患者的整体生命体征更加平稳，操作时间更短，术后满意度更高。【结论】解痉灵复合丙泊酚应用于无痛肠镜麻醉，患者具有更高舒适度和满意度，且不良反应少，安全性更高；可以临床推广应用。“,”[Objective] To explore clinical efficacy and safety of scopolamine butylbromide combined with propofol in painless enteroscopy ,and calculate the comfort and satisfaction of patients .[Methods] Totally 400 cases with gastrointestinal endoscopy were divided into 4 groups with 100 cases in each group .Group A re-ceived conventional gastrointestinal endoscopy under intravenous anesthesia with scopolamine butylbromide and propofol intravenous anesthesia .Group B received conventional gastrointestinal endoscopy under intravenous anesthesia with scopolamine butylbromide .Group C received conventional gastrointestinal endoscopy under in-travenous anesthesia with propofol .Group D only received conventional gastrointestinal endoscopy .The mean arterial pressure(MAP) ,heart rate(HR) and pulse oxygen saturation(SpO2 ) of each group before treatment , during the operation and at consciousness were recorded .The adverse reactions of patients were observed dur-ing the operation .The comfort and satisfaction of patients were investigated ,and the operation time was also recorded after operation .[Results] Compared with group B ,group C and group D ,adverse reactions during surgery were fewer ,and whole vital signs were more stable ,and the operation time was shorter ,and postoper-ative satisfaction was higher in group A .[Conclusion] Scopolamine butylbromide combined with propofol ap-plied in the anesthesia of painless enteroscopy has even higher degree of comfort and satisfaction ,fewer adverse reactions and greater safety .Therefore ,it is worthy of clinical promotion .