肥胖作为诱发机体胰岛素抵抗(Insulin Resistance,IR)、高脂血症、2型糖尿病(T2DM)等一系列代谢性疾病的主要诱因之一,已成为人类健康的巨大威胁。近年来,自噬(Autophagy)这一真核细胞特有的高度保守且被精密调控的机制引起了研究者的极大兴趣。最新研究显示,自噬对于调节机体脂肪代谢的平衡至关重要[1]。自噬主要通过作用于机 As a major inducer of a series of metabolic diseases such as insulin resistance (IR), hyperlipidemia and type 2 diabetes mellitus (T2DM), obesity has become a huge threat to human health. In recent years, the highly conserved and precisely regulated mechanism unique to autophagy, an eukaryotic cell, has drawn great interest from researchers. Recent research shows that autophagy is crucial for regulating the balance of body fat metabolism [1]. Autophagy mainly through the role of machine