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目的研究抗痫药物（ＡＥＤｓ）对男性癫痫患者性激素水平的影响。方法应用放射免疫分析法（ＲＩＡ）和免疫放射测定分析法（ＩＲＭＡ）测定应用多种ＡＥＤｓ治疗和未经治疗的男性癫痫患者及健康对照组血清睾酮（ＴＴ）、游离睾酮（ＦＴ）、性激素结合球蛋白（ＳＨＢＧ）、雌二醇（Ｅ２）、间质细胞刺激素（ＬＨ）、滤泡刺激素（ＦＳＨ）的水平。结果未治疗组与正常对照组相比，各项指标均无显著差异；各治疗组与对照组相比，ＦＴ水平均显著降低，ＳＨＢＧ水平显著升高；苯妥英钠治疗组的Ｅ２水平升高；而ＴＴ、ＬＨ、ＦＳＨ的水平各组间差别无统计学意义。结论ＡＥＤｓ可以影响男性癫痫患者性激素水平。
Objective To study the effects of antiepileptic drugs (AEDs) on sex hormone levels in male patients with epilepsy. Methods The levels of serum testosterone (TT), free testosterone (FT), and sex hormone in male patients with epilepsy and untreated AEDs were measured by radioimmunoassay (RIA) and immuno-radiometric assay (IRMA) Globulin (SHBG), estradiol (E2), interstitial cell stimulating hormone (LH), follicle stimulating hormone (FSH) levels. Results Compared with the control group, the untreated group had no significant difference in each index. Compared with the control group, the FT level was significantly decreased and the SHBG level was significantly increased in each untreated group. The E2 level was increased in the phenytoin sodium group. However, the levels of TT, LH and FSH were not significantly different between groups. Conclusion AEDs can affect sex hormones in male patients with epilepsy.