TNFα与TRAIL隶属于肿瘤坏死因子家族,它们共享某些信号通路,并导致细胞凋亡。尽管多数肿瘤细胞对这些凋亡因子敏感,但是有些却对其产生了抵抗性。最近,作者证实在TRAIL诱导的肿瘤细胞的凋亡中,c-Fos/AP-1的上调是一个必要非充分的条件。作者应用对TNFα与TRAIL不同敏感性的前 TNFα and TRAIL are members of the tumor necrosis factor family, which share certain signaling pathways and lead to apoptosis. Although most tumor cells are sensitive to these apoptotic factors, some are resistant to them. Recently, the authors confirmed that up-regulation of c-Fos / AP-1 is a necessary and insufficient condition in the TRAIL-induced apoptosis of tumor cells. The authors applied different sensitivities to TNFα and TRAIL before