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口服避孕药(OC)与绝经后用雌激素可改变血浆脂蛋白、肝、甲状腺或肾功能指数。妊娠时脂蛋白的变化性质类似于OC的影响,提示性激素起重要作用。本研究比较妊娠及服用OC对血糖、肝、肾及甲状腺功能的影响以及它们与血脂的关系。研究对象系从华盛顿州西雅图市。群体健康合作组(简称GHC)中随机选出,20～41岁妊娠36周妇女546名,20～39岁服OC者56名与未服OC者77名。所有研究对象均在禁食12～14小时后取血,由同一实验室在严格的内外质控下作系列临床化学测定,包括血糖、甲状腺素(T_4)、肌酐、总胆红素、SGOT、碱性磷酸酶(AlP)、球蛋白。此外还对全部孕妇作了血浆总蛋白、白蛋白与白/球蛋白比值测定,对其中285名孕妇还测定了血浆E_2、E_3、孕酮(P)及胎盘催乳素(HPL)。
Oral contraceptives (OC) and postmenopausal estrogen can alter plasma lipoprotein, liver, thyroid or renal function indices. Changes in the nature of lipoprotein during pregnancy similar to the impact of OC, suggesting that sex hormones play an important role. This study compared pregnancy and taking OC on blood glucose, liver, kidney and thyroid function and their relationship with blood lipids. The research object is from Seattle, Washington. Group Health Cooperative Group (GHC) were randomly selected 541 women aged 36 to 36 weeks of pregnancy 20 to 41 years old, 20 to 39 years old serving OC OC and 77 were not OC. All subjects were given blood 12 to 14 hours after fasting. A series of clinical chemistries including blood glucose, thyroxine (T 4), creatinine, total bilirubin, SGOT, Alkaline phosphatase (AlP), globulin. In addition, the plasma total protein, albumin and white / globulin ratio were also measured for all pregnant women, of which 285 pregnant women were also measured plasma E_2, E_3, progesterone (P) and placental lactogen (HPL).