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目的探讨FGFR1在乳腺浸润性小叶癌中的表达及意义。方法采用免疫组织化学染色检测FGFR1在45例乳腺浸润性小叶癌、40例乳腺浸润性导管癌中的表达,比较FGFR1在浸润性小叶癌和浸润性导管癌中表达的差异,分析浸润性小叶癌FGFR1的表达与临床病理参数的关系。结果 FGFR1在乳腺癌癌旁组织中均阴性表达。浸润性小叶癌FGFR1的阳性表达率比浸润性导管癌高(P=0.048),其染色强度也比浸润性导管癌强(P=0.044)。FGFR1的表达强度与乳腺浸润性小叶癌的肿块大小(P=0.021)和TNM分期相关(P=0.041)。结论初步推测FGFR1的过表达参与乳腺浸润性小叶癌的发生、发展。
Objective To investigate the expression of FGFR1 in breast invasive lobular carcinoma and its significance. Methods Immunohistochemical staining was used to detect the expression of FGFR1 in 45 cases of invasive lobular carcinoma of breast and 40 cases of infiltrating ductal carcinoma. The difference of FGFR1 expression between invasive lobular carcinoma and invasive ductal carcinoma was analyzed. Relationship between the expression of FGFR1 and clinicopathological parameters. Results FGFR1 was negatively expressed in paracancerous tissues of breast cancer. The positive rate of FGFR1 expression in invasive lobular carcinoma was higher than that in invasive ductal carcinoma (P = 0.048), and its staining intensity was also stronger than that in invasive ductal carcinoma (P = 0.044). The expression of FGFR1 was correlated with tumor size (P = 0.021) and TNM stage (P = 0.041) in invasive breast carcinoma. Conclusion It is preliminarily speculated that the overexpression of FGFR1 is involved in the occurrence and development of breast invasive lobular carcinoma.