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本文在肝微粒体水平上观察了环丙沙星、氧氟沙星和诺氟沙星对大鼠肝微粒体混合功能氧化酶活性的影响。以４００ｍｇ／ｋｇ环丙沙星、氧氟沙星和诺氟沙星灌胃，ｑｄ×７天后，环丙沙星组细胞色素ｂ５、氨基比林Ｎ－脱甲基酶、乙基吗啡Ｎ－脱甲基酶、ＮＡＤＰＨ－细胞色素Ｃ还原酶，７－乙氧基香豆素Ｏ－脱乙基酶和苯并（ａ）芘羟化酶被抑制，而氧氟沙星、诺氟沙星仅抑制ＮＡＤＰＨ－细胞色素Ｃ还原酶和苯并（ａ）芘羟化酶活性。三种药物对肝重及肝微粒体蛋白含量、细胞色素Ｐ－４５０和戊巴比妥钠侧链羟化酶活性均无影响。该结果对指导临床合理联合用药，减少副反应，避免药物蓄积中毒有重要意义。
The effect of ciprofloxacin, ofloxacin and norfloxacin on the activity of mixed functional oxidase in rat liver microsomes was observed at the level of liver microsomes. 400mg / kg ciprofloxacin, ofloxacin and norfloxacin gavage, qd × 7 days, ciprofloxacin group of cytochrome b5, aminopyrine N-demethylase, ethyl morphine N- Demethylase, NADPH-cytochrome C reductase, 7-ethoxycoumarin O-deethylase, and benzo (a) pyrene hydroxylase were inhibited while ofloxacin, norfloxacin Inhibits only NADPH-cytochrome C reductase and benzo (a) pyrene hydroxylase activity. The three drugs had no effect on liver weight, liver microsomal protein content, cytochrome P-450 and pentobarbital sodium side-chain hydroxylase activity. The results of clinical reasonable combination of guidance to reduce side effects, to avoid drug accumulation poisoning of great significance.