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Benzoic and salicylic acids in ointment sample were extracted with a 75% tehanol solution.The extracts are neutralized with tetramethylammonium hydroxide solution.Tetramethyl ammonium salts of benzoic and salicylic acids formed further react with 1 iodobutane directly in N,N dimethylformamide solution to form butyl esters of the corresponding acids.The separation of the butyl esters was carried out on column packed with 5% SE 30/102 Silanized white support.This method is simple and accurate.
Benzoic and salicylic acids in ointment samples were extracted with 75% tehanol solution. These extracts are neutralized with tetramethylammonium hydroxide solution. Tetramethyl ammonium salts of benzoic and salicylic acids formed further react with 1 iodobutane directly in N, N dimethylformamide solution to form butyl esters of the corresponding acids. The separation of the butyl esters was carried out on column packed with 5% SE 30/102 Silanized white support. This method is simple and accurate.