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目的:观察益气除疲合剂对胃肠道肿瘤病人淋巴细胞亚群的影响。方法:将62例患者随机分为两组。治疗组32例口服益气除疲合剂;对照组30例静点香菇多糖,4周后检测淋巴细胞亚群。结果:对照组治疗后总T淋巴细胞、总B淋巴细胞、CD4细胞、NK细胞均明显升高,CD8细胞明显下降,差异有统计学意义(P<0.05);治疗组治疗后总T淋巴细胞、CD4细胞、NK细胞均明显升高,差异有统计学意义(P<0.05),但CD8下降、总B淋巴细胞升高差异无统计学意义(P>0.05);两组间治疗后CD8、CD4/CD8差异有统计学意义(P<0.05),余数值差异无统计学意义(P>0.05)。结论:益气除疲合剂增强机体细胞免疫功能明显,与香菇多糖疗效相当,但增强体液免疫功能不及香菇多糖;而临床症状改善明显优于香菇多糖。
Objective: To observe the effect of Yiqi Fatigue on lymphocyte subsets in patients with gastrointestinal cancer. Methods: 62 patients were randomly divided into two groups. In the treatment group, 32 cases were treated with Yiqi addition and fatigue; in the control group, 30 cases of lentinan were intravenously injected, and the lymphocyte subsets were detected after 4 weeks. Results: After treatment, the total T lymphocytes, total B lymphocytes, CD4 cells and NK cells in the control group were significantly increased and CD8 cells were significantly decreased (P <0.05). After treatment, the total T lymphocytes (P <0.05). However, there was no significant difference between the two groups in the number of CD8, CD4 and NK cells (P <0.05) CD4 / CD8 difference was statistically significant (P <0.05), the remaining number difference was not statistically significant (P> 0.05). CONCLUSION: Yiqi addition to fatigue enhances cellular immune function of organism, which is equivalent to that of lentinan, but enhances humoral immunity less than lentinan. The improvement of clinical symptoms is obviously better than that of lentinan.