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近年来研究发现，氧化应激与抗氧化防御系统的失衡在慢性牙周炎中发挥重要作用，牙周组织受到细菌刺激产生的过量活性氧可造成和加重牙周组织的损伤。本文就炎性条件下过量活性氧对牙周组织的损害，以及氧化应激与抗氧化防御系统在慢性牙周炎发生发展中的作用和机制作一综述。“,”Reactive oxygen species (ROS )overproduction by periodontal tissues under bacterial stimuli can cause and aggravate the damages of periodontal tissues.This review focuses on the damages of periodontal tissues induced by ROS overproduction under inflammatory condition,as well as the roles and related mechanisms of oxidative stress and antioxidant defense system in the development of chronic periodontitis.