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目的:讨论药物性肾损害的临床特点。方法:回顾性分析56例药物性肾损害的临床资料。结果:引起肾损害的药物抗生素类占首位,其次为造影剂、甘露醇、环孢素,病人临床主要表现为急性肾功能衰竭、一过性血尿和(或)肾功能异常,治愈率83.9%。结论:引起肾损害的药物种类不同,其临床表现不同,了解药物代谢途径及肾损害机制,可减少药物性肾损害的发生。
Objective: To discuss the clinical features of drug-induced renal damage. Methods: A retrospective analysis of 56 cases of drug-induced renal damage in clinical data. Results: Antibiotics which caused renal damage accounted for the first place, followed by contrast agent, mannitol and cyclosporine. The main clinical manifestations of patients were acute renal failure, transient hematuria and / or renal dysfunction, and the cure rate was 83.9% . Conclusion: The types of drugs that cause kidney damage are different. Their clinical manifestations are different. Understanding the mechanism of drug metabolism and kidney damage can reduce the occurrence of drug-induced renal damage.