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221例肝硬化合并难治性腹水病人行间断、小量自体腹水回输治疗。腹水常规为漏出液者可行回输,每次放腹水1000～4000 ml,全部或大部分回输(加入100 ml:lmg 肝素)。结果除4例死亡外余17例腹水明显消退。回输后病人腹围、体重明显下降(P<0.01),尿量、血浆白蛋白明显升高(P<0.01),血尿素氮、肌酐清除率改善(P<0.05),尿钠增加。其治疗机理为:腹水回输后可(1)增加血容量及肾灌注量使肌酐清除率及尿量增加。(2)血浆白蛋白及胶渗压升高。(3)打破了由肾血管收缩及血管紧张素、醛固酮增高引起的恶性循环。
221 patients with cirrhosis and refractory ascites interrupted, a small amount of autologous ascites transfusion therapy. Ascites routine leakage of liquid feasible viable, each ascites 1000 ~ 4000 ml, all or most of the back (add 100 ml: lmg heparin). Results in addition to 4 cases of extra-17 cases of ascites significantly subsided. After transfusion, the patient’s abdominal circumference and body weight decreased significantly (P <0.01), urine output and plasma albumin increased significantly (P <0.01), and blood urea nitrogen and creatinine clearance rate improved (P <0.05). The treatment mechanism is as follows: (1) increased blood volume and renal perfusion after creatinine clearance and urine output increased. (2) elevated plasma albumin and plastic osmotic pressure. (3) Breaking the vicious cycle caused by renal vasoconstriction and angiotensin and aldosterone increase.