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日本制成的自发型瘦型糖尿病(NOD)小鼠动物模型与人IDDM相似,我们对NOD小鼠的胰岛炎发病过程进行了详细的观察研究,并将其特点和人IDDM时的胰岛和血中抗体所见作对比性研究。 NOD小鼠发生胰岛炎前,首先在胰岛β细胞内出现特异性的ClassⅡ MHC抗原(Ia抗原),并可用逆转录病毒(retrovirus)的抗血清证明在一部分β细胞内存在逆转录病毒粒子。我们用光镜和电镜观察到,5～6周龄以后的NOD小鼠胰岛中的浸润细胞的大部分是淋巴细胞,并进一步用单克隆抗体进行分析后,证明主要是由T细胞组成,其中多数是Lyt-1~+,L3T4 T细胞。然后,
The animal model of spontaneous NOD mice made in Japan is similar to that of human IDDM. We have conducted a detailed observation of the pathogenesis of insulitis in NOD mice and compared its characteristics with islet and blood Antibodies seen for the comparative study. Before NOD mice developed insulitis, specific Class II MHC antigens (Ia antigens) appeared in islet beta cells, and retrovirus sera could be used to confirm the presence of retroviral particles in some beta cells. Using light microscopy and electron microscopy, we observed that the majority of infiltrating cells in the islets of NOD mice 5- to 6-weeks-old were lymphocytes and further analysis with monoclonal antibodies proved to be mainly composed of T cells, of which Most are Lyt-1 ~ +, L3T4 T cells. then,