星形胶质细胞作为中枢神经系统中最丰富的神经胶质细胞,是中枢神经系统最主要的支持细胞,为神经元提供营养支持和保护作用。在肌萎缩脊髓侧索硬化症(ALS)发病过程中,退行性病变的神经元以及过度激活的胶质细胞将导致神经元所处微环境恶化,使神经元的损伤进行性加重。因此,研究星形胶质细胞与运动神经元的关系对探讨ALS的发病机制及其干预治疗具有非常重要的意义。 Astrocytes, as the most abundant glial cells in the central nervous system, are the most important supporting cells in the central nervous system and provide neurotrophic support and protection. During the development of ALS, degenerative neurons and overactive glial cells will lead to the deterioration of neuron’s microenvironment and progressive increase of neuronal damage. Therefore, the study of the relationship between astrocytes and motor neurons is of great significance to explore the pathogenesis of ALS and its interventional therapy.