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目的:探讨鼻咽癌细胞DNA含量和癌细胞核形态参数与放射敏感性的关系。方法:收集51例放疗前鼻咽癌组织标本,Feulgen染色和图像分析法检测鼻咽癌DNA含量和细胞核的形态定量参数。结果:51例鼻咽癌组织中,完全消退组DNA指数、DNA异倍体细胞所占百分率、细胞核形态参数面积、周长和直径均比残留组高。结论:DNA含量和癌细胞核形态参数是反映鼻咽癌放射敏感性和预测其近期疗效的重要指标。
Objective: To investigate the DNA content of nasopharyngeal carcinoma cells and the relationship between nuclear morphological parameters and radiosensitivity. Methods: Totally 51 cases of nasopharyngeal carcinoma before radiotherapy were collected. DNA content and nuclear morphological parameters of nasopharyngeal carcinoma were detected by Feulgen staining and image analysis. Results: In 51 cases of nasopharyngeal carcinoma, DNA index, percentage of DNA aneuploid cells, nucleus parameter area, circumference and diameter of complete regression group were higher than that of the residual group. Conclusion: DNA content and nuclear morphological parameters of cancer cells reflect the radiosensitivity of nasopharyngeal carcinoma and predict its short-term curative effect.