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目的:探讨外周血正五聚蛋白3（PTX3）和成纤维细胞生长因子2（FGF2）的水平与SLE患者的临床表现、免疫学指标和疾病活动度的相关性。方法:收集54例SLE患者和34名健康对照者的外周血标本。对SLE患者和健康对照者的一般情况、临床资料、疾病活动度进行相应评估。ELISA法检测外周血中的PTX3和FGF2的浓度。采用n t检验、Mann-Whitney n U检验和Spearman秩相关进行统计学相关分析。n 结果:与健康对照相比较，SLE患者血浆PTX3水平明显增高[（3 191±2 423） pg/ml和（755±432） pg/ml，n t=5.595，n P<0.01]，其中血液系统受累患者滴度高于未受累患者[（3 810±2 840） pg/ml和（2 493±1 830） pg/ml，n t=2.008，n P=0.049]，并与尿蛋白定量（24 h）（n r=0.498 6，n P=0.005 9）及ESR（n r=0.376，n P=0.007）、SLEDAI评分（n r=0.405，n P=0.003）呈正相关，与补体C3呈负相关（n r=-0.405，n P=0.005）。SLE患者FGF2的血浆水平随着PTX3升高（n r=0.304，n P=0.029），并与SLEDAI评分呈正相关（n r=0.326，n P=0.019），与C3（n r=-0.414，n P=0.004）、C4补体（n r=-0.451，n P=0.007）呈负相关。此外，SLE患者中抗NuA抗体[（138±91） pg/ml和（59±68） pg/ml，n t=2.996，n P=0.004 2]、抗dsDNA抗体[（120±96） pg/ml和（56±58） pg/ml，n t=3.583，n P=0.000 7]和抗-rRNP抗体[（151±109） pg/ml和（63±61） pg/ml，n t=3.757，n P=0.000 4]阳性者FGF2的水平高于阴性患者。n 结论:外周血PTX3和FGF2的水平对于SLE的疾病活动度和临床表型的判断具有指导作用，可以在临床工作中帮助医生更好地做出诊治决策。“,”Objective:To elucidate the correlation between peripheral blood levels of pentraxin 3 (PTX3) and fibroblast growth factors 2 (FGF2) and clinical manifestations, immunological indexes and disease activity of systemic lupus erythematosus (SLE) patients.Methods:The correlation between peripheral blood levels of PTX3 and FGF2 and clinical manifestations, immunological indexes and disease activity of SLE pa-tients was determined. n T test, Mann-Whitney n U test and Spearman's rank correlation coefficient were analyzed statistically.n Results:Plasma PTX3 levels were significantly higher in SLE patients than in healthy controls (3 191±2 423) pg/ml n vs (755±432) pg/ml, n t=5.595, n P<0.01) . The titer of PTX3 in patients with hematologic in-volvement was higher than that in the patients without [(3 810±2 840) pg/mln vs (2 493±1 830) pg/ml, n t=2.008, n P=0.049). Plasma PTX3 concentration in SLE patients was positively correlated not only with the level of 24 h urine protein (n r=0.498 6, n P=0.005 9), but also with ESR (n r= 0.376, n P=0.007) and systemic lupus erythematosus disease activity index (SLEDAI) scores (n r=0.405, n P=0.003). On the contrast, plasma PTX3 concentration in SLE patients was negatively correlated with complement 3 (n r=-0.405, n P=0.005). Increased serum PTX3 levels accompanied by increased serum FGF2 levels was observed. Plasma FGF2 concentration in SLE patients was positively correlated with SLEDAI scores (n r=0.326, n P=0.019), but negatively correlated with level of comple-ment 3 (n r=-0.414, n P=0.004) and complement 4 (n r=-0.451,n P=0.007). Levels of FGF2 were higher in patients with positive anti-NuA antibody [(138±91) pg/ml n vs (59±68) pg/ml, n t=2.996, n P=0.004 2), anti-dsDNA antibody [(120±96) pg/ml n vs (56±58) pg/ml, n t=3.583, n P=0.000 7] and anti-rRNP antibody (151±109) pg/ml n vs (63±61) pg/ml, n t=3.757, n P=0.000 4) than in patients with negative of these antibodies.n Conclusion:The levels of PTX3 and FGF2 in peripheral blood may play a role in determining the disease activity and clinical phenotype of SLE, and can help doctors to make diagnosis and treatment decisions.