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交插结构可能是生物膜系统中普遍存在的一种结构,它可能在膜中构成几个结构域(domain)来调节膜脂的流动性、通透性等物理性质,也可能通过改变结合于交插脂双层的膜蛋白的结构来行使生理功能。许多药物可以诱导非交插脂双层形成交插结构,例如可卡因和pindolol诱导磷脂酰胆碱、山莨菪诱导磷脂酰甘油形成交插脂双层结构。阿托品是与山莨菪碱同族的生物碱,是一种抗胆碱药物,它具有抑制腺体分泌、扩大瞳孔、解除胃肠和支气管平滑肌痉挛、解救有机磷中毒等功能。本文利用差式扫描量热(DSC)和荧光标记法研究了阿托品对二棕榈酰磷脂酰甘油(DPPG)的作用,证明阿托品可诱导DPPG脂质体形成交插结构。
Intercalator structure may be a common biofilm structure in the system, it may form several domains in the membrane (membrane) to regulate fluidity, permeability and other physical properties, but also by changing the binding Lipid bi-layer membrane protein structure to exercise physiological function. Many drugs can induce non-intercalary lipid bilayers to form interleaved structures, such as cocaine and pindolol-induced phosphatidylcholine, and anisodamine-induced phosphatidylglycerol to form an amphipathic bilayer structure. Atropine is the same alkaloid and anisodamine, is an anticholinergic drugs, it has the inhibition of glandular secretion, enlargement of the pupil, relieve spasms of gastrointestinal and bronchial smooth muscle, organophosphate poisoning and other functions. In this paper, the effect of atropine on dipalmitoylphosphatidylglycerol (DPPG) was studied by differential scanning calorimetry (DSC) and fluorescent labeling, demonstrating that atropine can induce DPPG liposomes to form an interleaved structure.