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目的:总结成人7型腺病毒感染的临床特点和发展规律,观察复方青花颗粒治疗腺病毒感染的临床疗效。方法:选择确诊的成人7型腺病毒感染175例,总结分析其临床特点;将符合纳入标准的139例随机分为复方青花颗粒组、连花清瘟颗粒组和感冒清热颗粒组,比较3组退热时间及治疗24h后的体温。结果:患者常见症状体征依次为咳嗽、咽干咽痛、咳痰、咽部淋巴滤泡增生、扁桃体增大、乏力、鼻塞流涕、肌肉酸痛、腹泻及头痛头晕;外周血白细胞计数升高占20.6%,单核细胞比例升高占55.3%,肝功能异常占9.7%,影像学检查提示肺炎15例(8.6%)。治疗24h后复方青花颗粒组和连花清瘟颗粒组体温非常显著低于感冒清热颗粒组(P<0.01),退热时间显著短于感冒清热颗粒组(P<0.05)。结论:此次7型腺病毒传染性强,但症状较轻,主要表现为咳嗽、咳痰、咽痛等。复方青花颗粒与连花清瘟颗粒辅助治疗腺病毒感染疗效相近,均优于感冒清热颗粒,在腺病毒疫情暴发流行时可作为早期治疗的选择药物之一。
OBJECTIVE: To summarize the clinical features and development of adult adenovirus type 7 infection and to observe the clinical efficacy of compound Qinghua granule in the treatment of adenovirus infection. Methods: One hundred and seventy five cases of adult adenovirus type 7 were selected for diagnosis. The clinical features were summarized and analyzed. One hundred and ninety-nine patients who met the inclusion criteria were randomly divided into Compound Qinghua Granule Group, Lianhua Qingwen Granule Group and Qinggan Qingre Granule Group. Antipyretic time and body temperature after treatment for 24h. Results: The symptoms and signs of patients were cough, pharyngopharyngeal sore throat, expectoration, pharyngeal lymphoid follicular hyperplasia, tonsil enlargement, weakness, nasal obstruction and runny nose, muscle soreness, diarrhea and headache and dizziness. The peripheral white blood cell count increased 20.6%, monocyte increased 55.3%, hepatic dysfunction accounted for 9.7%, imaging examination prompted pneumonia 15 cases (8.6%). The body temperature of Compound Qinghua Granule Group and Lianhua Qingwen Granule Group after 24 hours of treatment were significantly lower than those of Qingganqing Granule group (P <0.01), and the antipyretic time was significantly shorter than that of Qingreqing Granule group (P <0.05). Conclusion: The adenovirus type 7 is contagious, but the symptoms are mild, mainly manifested as cough, expectoration, sore throat and so on. Compound Qinghua Granules and Lianghua Qingwen granules adjuvant treatment of adenovirus infection similar efficacy, are better than the flu Qingre granules in the outbreak of the epidemic of adenovirus can be used as one of the early treatment options.