论文部分内容阅读
目的探讨采用超声定量诊断技术测定肝脏超声声强在弥漫性脂肪肝诊断中的临床价值;分析脂肪肝轻重程度与生化指标值之间的关系。方法 120例(不同程度)弥漫性脂肪肝患者和40例健康对照者纳入研究。根据氢质子磁共振波谱(proton magnetic resonance spectroscopy,1 H-MRS)检查计算的脂肪分数值将患者分为轻、中、重度三组,应用超声定量诊断技术测定右肝及左肝二维图像的感兴趣区(region of interest,ROI)的回声强度(echo intensity,EI)值,收集生化指标天冬氨酸氨基转移酶(aspartatr aminotransferase,AST)、丙氨酸氨基转移酶(alanine aminotransferase,ALT)以及空腹血糖(fasting blood glucose,FBG)值,分析各定量指标与脂肪肝严重程度的关系。结果右肝近场、右肝中场、右肝后场和左肝EI值、ALT、AST值在正常组、轻、中、重度脂肪肝组组间均存在统计学差异(P<0.05);脂肪肝分度与右肝近场、右肝中场、右肝和左肝EI值及ALT、AST、FBG均呈显著相关(P<0.05)。结论采用超声定量诊断技术测定肝脏的EI值能够直接反映脂肪肝病变程度,可为临床分级诊断提供量化的客观信息。
Objective To investigate the clinical value of quantitative ultrasound in the diagnosis of diffuse fatty liver and to analyze the relationship between the severity of fatty liver and the biochemical parameters. Methods 120 cases (varying degrees) of diffuse fatty liver disease patients and 40 healthy controls were included in the study. The patients were divided into mild, moderate and severe groups by proton magnetic resonance spectroscopy (1 H-MRS), and the patients were divided into three groups: light, medium and severe. The echo intensity (EI) values of the region of interest (ROI) were collected. The biochemical indicators such as aspartate aminotransferase (AST), alanine aminotransferase (ALT) And fasting blood glucose (FBG) values were analyzed to analyze the relationship between the quantitative indexes and the severity of fatty liver. Results The values of EI, ALT and AST in the right and left liver midfield, right hind field and left liver in the normal group, mild, moderate and severe fatty liver group were all significantly different (P <0.05). The index of fatty liver was significantly correlated with the values of EI, ALT, AST and FBG in the right and left liver midfield, right and left liver (P <0.05). Conclusion The quantitative determination of EI by using the ultrasonic quantitative diagnostic technique can directly reflect the degree of fatty liver disease and provide quantitative objective information for clinical grade diagnosis.