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３４例急性白血病经诱导治疗达完全缓解后，分２组接受中枢神经系统（ＣＮＳ）的预防性治疗，Ａ组颅脑放疗，Ｂ组静注氨甲喋呤（ＭＴＸ），２组均作鞘注化疗。在ＣＮＳ防治后作生长激素（ＧＨ）刺激试验，在治疗过程中观察病儿生长，并与单纯化疗组对照比较。结果表明，Ａ，Ｂ两组分别有６６．７％和４３．８％病儿出现ＧＨ缺乏，与单纯化疗组比较，差异有极显著性（Ｐ＜０．０１）。治疗２年后，身高增长指数下降＞０．５０ｓ者，Ａ组５５．６％，Ｂ组５０．０％，与单纯化疗组比较差异均有显著性（Ｐ均＜０．０５）。提示Ａ，Ｂ两组生长缓慢可能与其治疗引起的下丘脑－垂体功能不全有关。
Thirty-four patients with acute leukemia were treated with induction therapy for complete remission. Two groups received prophylactic treatment of central nervous system (CNS), group A craniocerebral radiotherapy, group B methotrexate (MTX), and group 2 received intrathecal chemotherapy. After the prevention and treatment of CNS for growth hormone (GH) stimulation test, observe the growth of sick children in the course of treatment, and compared with the simple chemotherapy group. The results showed that GH deficiency was found in 66.7% and 43.8% of children in group A and B, respectively. The difference was significant (P <0.01) compared with the chemotherapy alone group. After 2 years of treatment, the height growth index decreased> 0.50s, 55.6% in group A and 50.0% in group B, which were significantly different from those in chemotherapy alone group (all P <0.05). Tip A, B slow growth may be related to the treatment of hypothalamic-pituitary dysfunction.