党参水煎剂灌胃和腹腔给药的LD_(50)分别为44.5与29.2g/kg,其正丁醇提取物(Ⅲ)腹腔与静脉给药的LD_(50)分别为7.6与1.7g/kg。党参水煎剂在灌胃、皮下、腹腔给药后,Ⅲ在静脉给药后,能使血浆皮质酮含量显著升高。Ⅲ能使血浆ACTH含量显著增高,并能对抗地塞米松的降血浆皮质酮作用,提示其作用部位在垂体或垂体以上水平。 The LD_ (50) of Codonopsis decoction intraperitoneal and intraperitoneal administration were 44.5 and 29.2g / kg respectively. The LD_ (50) of intraperitoneal and intravenous administration of n-butanol extract (Ⅲ) were 7.6 and 1.7g / kg. Codonopsis decoction in the gavage, subcutaneous, intraperitoneal administration, Ⅲ after intravenous administration, can make plasma corticosterone content was significantly increased. Ⅲ can significantly increase the plasma ACTH content, and dexamethasone can reduce plasma corticosterone role, suggesting that the role of the site above the pituitary or pituitary level.