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目的观察雷公藤多苷片治疗类风湿关节炎的临床疗效及药物不良反应发生情况。方法选取医院收治的类风湿性关节炎患者116例,随机分为观察组和对照组,每组58例。对照组采用历节胶囊治疗,观察组采用历节胶囊联合雷公藤多苷片治疗。观察2组治疗总有效率,治疗前后关节疼痛个数、关节功能分级及药物不良反应发生情况。结果观察组治疗总有效率为93.1%,高于对照组的77.6%(P<0.05)。治疗后,观察组关节压痛个数少于对照组,关节功能分级低于对照组(P<0.05)。2组不良反应发生率分别为5.2%、3.4%,组间比较差异无统计学意义(P>0.05)。结论雷公藤多苷片治疗类风湿关节炎能改善疗效,促进关节功能恢复,且不良反应少。
Objective To observe the clinical efficacy and toxicity of tripterygium wilfordii polyglycoside tablets in the treatment of rheumatoid arthritis. Methods A total of 116 patients with rheumatoid arthritis admitted to hospital were randomly divided into observation group and control group, 58 cases in each group. The control group was treated with Lijie capsule, and the observation group was treated with Lijie capsule and Tripterygium glycosides tablets. The total effective rate of two groups was observed, the number of joint pain before and after treatment, the classification of joint function and the incidence of adverse drug reactions. Results The total effective rate of the observation group was 93.1%, which was higher than that of the control group (77.6%, P <0.05). After treatment, the number of joint tenderness in the observation group was less than that in the control group, and the joint function classification was lower than that in the control group (P <0.05). The incidence of adverse reactions in the two groups were 5.2% and 3.4%, respectively, with no significant difference between the two groups (P> 0.05). Conclusion Tripterygium glycosides tablet treatment of rheumatoid arthritis can improve the efficacy and promote joint function recovery, and less adverse reactions.