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目的探讨胰腺黏液性肿瘤的诊断和治疗。方法对1999年1月至2007年6月我院腹部外科收治的经病理证实的22例胰腺黏液性肿瘤的临床资料进行回顾性分析。结果胰腺导管内乳头状黏液性肿瘤3例,黏液非囊性癌11例,黏液性囊性肿瘤8例。临床表现无特异性,影像学检查难以确诊。22例均行手术治疗,术后2例失访。黏液性囊性肿瘤术后1例因复发转移死亡;导管内乳头状黏液性肿瘤1例出现复发转移死亡;黏液非囊性癌失访2例,其余均于5～22个月内死亡,平均生存期10个月。结论胰腺黏液性肿瘤是一种恶性或潜在恶性病变。胰腺导管内乳头状黏液性肿瘤和胰腺黏液性囊性肿瘤根治性切除术后疗效满意,胰腺黏液非囊性癌预后差,生物学特点有待于进一步研究。
Objective To investigate the diagnosis and treatment of pancreatic mucinous neoplasms. Methods The clinical data of 22 cases of pancreatic mucinous tumors confirmed by pathology in our hospital from January 1999 to June 2007 were analyzed retrospectively. Results Three cases of papillary mucinous carcinoma in pancreatic duct, 11 cases of mucinous noncystic carcinoma and 8 cases of mucinous cystic tumor. Non-specific clinical manifestations, imaging diagnosis difficult to diagnose. Twenty-two patients underwent surgery and 2 patients were lost to follow-up. One case of mucinous cystic neoplasm died of recurrence and metastasis. One case of intraductal papillary mucinous neoplasm had recurrence and metastasis, two cases of mucinous noncystic carcinoma were lost and the rest died within 5-22 months, with an average of Survival of 10 months. Conclusions Pancreatic mucinous neoplasm is a malignant or potentially malignant disease. Pancreatic ductal papillary mucinous tumor and pancreatic mucinous cystic tumor after radical resection of the curative effect is satisfactory, pancreatic mucinous non-cystic carcinoma of poor prognosis, the biological characteristics need further study.