目的：观察慢性肾炎（ＣＧＮ）时血小板α－颗粒膜蛋白（ＧＭＰ１４０）活性的改变及其与肾小球滤过率（ＧＦＲ）的关系。方法：采用抗人活化血小板α－颗粒膜蛋白１２５Ｉ标记的单克隆抗体，以单位点放射免疫法直接定量测定４３例ＣＧＮ患者和２０例正常人血小板ＧＭＰ１４０，并用９９ｍＴｃＤＴＰＡ检测ＧＦＲ。结果：发现ＣＧＮ患者ＧＭＰ１４０分子数显著高于正常对照组，随ＧＦＲ下降ＧＭＰ１４０也逐渐下降，二者呈正相关。结论：ＧＭＰ１４０测定有助于肾小球疾病发病机理及进行性肾脏损害的研究，对于抗血小板药物的选用具有指导意义 Objective: To observe the changes of platelet α-granule membrane protein (GMP140) activity in chronic nephritis (CGN) and its relationship with glomerular filtration rate (GFR). Methods: Monoclonal antibodies against human activated platelet α-granule membrane protein 125I were used to determine the platelet GMP140 in 43 CGN patients and 20 normal persons by radioimmunity assay. GFR was detected by 99mTcDTPA. Results: The number of GMP140 molecules in CGN patients was significantly higher than that in the normal control group, with the GFR decreased GMP140 also gradually decreased, the two was positively correlated. Conclusion: The GMP140 assay can contribute to the pathogenesis of glomerular diseases and progressive renal damage, which is instructive for the selection of antiplatelet drugs