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目的报道1例肾原发性神经内分泌癌,并探讨其病理学特征及其鉴别诊断。方法对1例肾神经内分泌癌进行光镜及免疫组化标记,并结合文献复习。结果肿瘤位于肾中上极,大小为4.5 cm×3.5 cm×2.5 cm。光镜示以巢状结构为主,肿瘤细胞密集异型,小圆形及小梭形,胞质少,核富于染色质,核仁不明显,局部区域富于核分裂象,伴灶性出血、坏死。免疫组化示瘤细胞CgA、Syn、NSE、AE1/AE3和bcl-2(+)。结论肾神经内分泌癌是一种少见的恶性肿瘤,其诊断需结合组织形态及免疫表型。
Objective To report a case of primary neuroendocrine carcinoma of the kidney and to explore its pathological features and differential diagnosis. Methods One case of neuroendocrine carcinoma was stained with light microscopy and immunohistochemistry, and combined with literature review. Results The tumor was located in the upper pole of the kidney with a size of 4.5 cm × 3.5 cm × 2.5 cm. Light microscopy showed a nested structure with densely-shaped tumor cells, small round and small fusiform, less cytoplasm, nuclear rich in chromatin, nucleoli are not obvious, the local area is rich in mitosis, with focal hemorrhage, Necrosis. Immunohistochemistry showed tumor cells CgA, Syn, NSE, AE1 / AE3 and bcl-2 (+). Conclusion Renal neuroendocrine carcinoma is a rare malignant tumor, its diagnosis should be combined with histomorphology and immunophenotype.