研制安全、廉价和有效疫苗的注意力,重新回到免疫学基本原理上,即体液免疫应答的产生需要B和T淋巴细胞之间的合作;小分子抗原只有与可被T细胞识别的蛋白质共价结合后才能诱生免疫力;免疫反应性取决于个体人白细胞抗原(HLA)的基因型,并与个体的组织相容性(MHC)抗原能否与免疫原片段结合有关。最近,一些文献介绍了应用这些原理改进合成肽疫苗成分的应用。这些办法是否能产生有效肽疫苗还有待观察,但这些实验无疑会产生有效的研究方法。两个打算研制疟疾和口蹄疫病毒疫苗的 The development of safe, cheap and effective vaccines has returned to the immunological rationale that the humoral immune response requires cooperation between B and T lymphocytes; small molecule antigens only bind to proteins that are recognized by T cells The combination of immunogenicity and immunogenicity depends on the genotype of individual human leukocyte antigen (HLA) and whether the individual’s histocompatibility (MHC) antigen can bind to the immunogenic fragment. Recently, some papers describe the application of these principles to improve the composition of the synthetic peptide vaccine. Whether these approaches can produce an effective peptide vaccine remains to be seen, but these experiments will undoubtedly produce effective research methods. Two plans to develop malaria and foot-and-mouth disease virus vaccine