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目的:观察鹿瓜多肽注射液对强直性脊柱炎(AS)患者血清内脏脂肪组织来源的丝氨酸蛋白酶抑制剂(visceraladipose tissue-derived serine protease inhibitor,Vaspin)水平的影响,阐明Vaspin在强直性脊柱炎发生过程中可能的作用机制。方法:采用酶联免疫法测定AS患者鹿瓜多肽注射液治疗前后血清Vaspin水平及炎症因子浓度,并分析血清Vaspin水平与炎症因子间的相互关系。结果:AS组血清Vaspin水平明显高于正常对照组(1.79±0.27vs.0.72±0.08μg/L,P<0.01)。AS组患者血清Vaspin水平与TNF-α及BASDAI呈正相关(r=0.454,P<0.05和r=0.328,P<0.01)。TNF-α是影响空腹血清Vaspin水平的独立相关因素。AS组经鹿瓜多肽注射液治疗后ESR、CRP、TNF-α、BAS-DAI及BASFI均显著降低(均P<0.01),血清Vaspin水平也显著降低(1.79±0.27vs.1.26±0.07μg/L,P<0.01)。结论:鹿瓜多肽注射液能有效抑制致炎性细胞因子产生,控制和延缓疾病活动,同时降低血清Vaspin水平。
Objective: To observe the effect of Lugua Polypeptide Injection on serum visceral adipose tissue-derived serine protease inhibitor (Vaspin) in patients with ankylosing spondylitis (AS) and to elucidate the role of Vaspin in ankylosing spondylitis Possible mechanism of action in the process. Methods: Serum Vaspin levels and inflammatory cytokines levels were measured by ELISA before and after treatment. The relationship between serum Vaspin levels and inflammatory cytokines was analyzed. Results: The serum Vaspin level in AS group was significantly higher than that in control group (1.79 ± 0.27 vs.0.72 ± 0.08 μg / L, P <0.01). Serum Vaspin levels in patients with AS were positively correlated with TNF-αand BASDAI (r = 0.454, P <0.05 and r = 0.328, P <0.01). TNF-α is an independent factor affecting fasting serum Vaspin levels. The levels of ESR, CRP, TNF-α, BAS-DAI and BASFI in AS group were significantly decreased (all P <0.01) and the levels of Vaspin in serum were significantly lower (1.79 ± 0.27 vs. 1.26 ± 0.07 μg / L, P <0.01). Conclusion: Lugua polypeptide injection can effectively inhibit the production of inflammatory cytokines, control and delay the disease activity, and reduce the serum Vaspin level.