在静息状态时 ,核因子 κB((nuclearfactorκB ,NF κB)通常与其抑制物以无活性的复合物形式存在于胞浆 ,当受到胞外信号刺激时 ,通过一个或多个信号转导途径 ,激活一系列激酶 ,迅速从胞浆易位到胞核 ,调控相应靶基因的表达。目前发现它是免疫和炎症反应的主要调节因子 ,也参与胚胎发育、细胞周期的调控、细胞凋亡的调节 ,NF κB的过度表达与多种疾病的免疫病理机制有关。近年来许多学者深入探讨了NF κB信号转导途径的调节机制 ,使得许多疾病的发病机制得以进一步阐明 ,并最终为其治疗提供了理论基础 At rest, nuclear factor κB (NFκB) is usually present in the cytoplasm as an inactive complex with its inhibitor, which, when stimulated by extracellular signals, passes through one or more signal transduction pathways, Activation of a series of kinases rapidly translocates from the cytoplasm to the nucleus and regulates the expression of the corresponding target genes and is now found to be the major regulator of immune and inflammatory responses as well as involved in embryonic development, regulation of the cell cycle, regulation of apoptosis , NFκB overexpression and immune diseases pathological mechanisms.Many scholars in recent years, in-depth discussion of NFκB signaling pathway regulation mechanism, making the pathogenesis of many diseases can be further clarified, and ultimately for its treatment provided Theoretical basis