脂质体作为一种药物剂型,需要严格的质量控制细则,如脂质体囊大小,包囊率等。传统的分析方法需要将囊分离破坏,采用层析、离心、放射或荧光标记技术,用HPLC法进行分析测定。下面介绍用光子相关光谱法(PCS)和~(19)F核磁共振光谱法(NMR)测定氟米松或地塞米松单层脂质体的理化特性,而 Liposomes as a pharmaceutical dosage form, require strict quality control rules, such as the size of the liposome vesicles, cysts and so on. Traditional analysis methods require the separation and destruction of the capsule using chromatographic, centrifugation, radioactive or fluorescent labeling techniques, and analysis by HPLC. The physical and chemical properties of flumetasone or dexamethasone monolayer liposomes are determined by photon correlation spectroscopy (PCS) and ~ (19) F nuclear magnetic resonance spectroscopy (NMR)